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Jingdong book

分子麻醉学

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Jingdong book

分子麻醉学

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《分子麻醉学》系统介绍了麻醉学研究领域的科学问题如全麻机制、器官保护、脓毒症、急性肺损伤、疼痛发生机制及其干预等的现状和进展，并对若干基本问题和重点、热点问题进行了详细的阐述。全书共分二十七章：第一章介绍了分子麻醉学研究相关的理论和技术，简要概述了国内外麻醉学研究的几个前沿问题；第二到十七章讨论了全身麻醉的产生机制，阐述了围术期器官保护和麻醉相关并发症的分子机制；第十八到二十三章讨论了危重症医学领域的脓毒症、ALI／ARDS等的发病机制和防治问题，以及危重病相关的中枢神经系统功能障碍和细菌耐药性问题；第二十四到二十七章阐述了不同类型疼痛的发生机制及研究进展。
《分子麻醉学》既可作为高等医学院校麻醉学专业研究生教材，也可供麻醉工作者及相关研究、教学人员参考。
Catalogue

序
前言
第一章 分子麻醉学研究进展
第一节 概述
第二节 分子麻醉学研究相关的理论与技术
第三节 分子麻醉学研究的前景与展望

第二章 睡眠、觉醒、意识与全麻机制研究
第一节 睡眠与觉醒的机制
第二节 意识的产生与维持及其机制
第三节 睡眠与全麻意识消失
第四节 全麻意识消失与病理性意识紊乱

第三章 全麻药作用的分子机制
第一节 概述
第二节 膜脂质学说
第三节 蛋白质学说
第四节 突触传递学说
第五节 全麻分子机制研究展望

第四章 配体门控离子通道与全麻机制研究
第一节 配体门控离子通道在中枢神经系统的分布
第二节 全麻药物蛋白分子靶位的研究工具
第三节 配体一受体作用的分子机制及对意识的影响
第四节 总结和展望

第五章 电压门控离子通道与全麻机制研究
第一节 与全麻药物作用相关的离子通道
第二节 与全麻药物作用相关的信号转导通路
第三节 常用实验模型

第六章 麻醉药对发育期神经系统的毒性作用研究
第一节 概述
第二节 麻醉药对发育期神经系统的毒性作用的证据
第三节 麻醉药对发育期神经系统的毒性作用的机制
第四节 总结与评价

第七章 术后认知功能障碍
第一节 概述
第二节 术后认知功能障碍的发生机制及研究进展
第三节 术后认知功能障碍的早期预警和防治的分子靶标
第四节 麻醉、阿尔茨海默病与术后认知功能障碍

第八章 遗传学与全麻机制
第一节 概述
第二节 全麻机制遗传学研究的常用方法
第三节 全麻敏感性相关基因研究的生物模型
第四节 总结与展望

第九章 局麻药的作用机制及研究进展
第一节 外周神经传递和局麻药的作用机制
第二节 局麻药毒性反应的分子机制
第三节 局麻药的新用途及其作用机制
第四节 常用的实验研究技术和模型

第十章 脑和脊髓保护
第一节 围术期脑和脊髓损伤的发生机制
第二节 预处理诱导脑和脊髓保护作用的机制
第三节 其他脑和脊髓保护措施及其机制
第四节 实验研究的意义和局限性
第五节 神经外科围术期脑保护策略

第十一章 心脏保护
第一节 心肌缺血一再灌注损伤／保护的神经源性机制
第二节 缺血性心脏病心肌损伤的常用实验模型
第三节 缺血预适应的分子机制
第四节 心肌缺血一再灌注损伤保护的机制和策略

第十二章 肠缺血一再灌注损伤的研究进展
第一节 自由基和肠缺血再灌注损伤
第二节 免疫系统与肠缺血一再灌注损伤
第三节 凋亡与肠缺血一再灌注损伤
第四节 缺血预（后）处理与肠缺血一再灌注损伤
第五节 能量代谢与肠缺血一再灌注损伤
第六节 其他方面与肠缺血一再灌注损伤

第十三章 围术期凝血功能紊乱
第一节 概述
第二节 血浆成分改变所致凝血功能紊乱的作用机制
第三节 弥散性血管内凝血

第十四章 血液保护与容量治疗
第一节 概述
第二节 血液保护措施与免疫
第三节 血浆代用品对组织氧代谢和炎症反应的影响

第十五章 应激反应的调节与控制
第一节 应激的全身反应机制
第二节 应激的细胞反应机制
第三节 应激的遗传学基础

第十六章 围术期过敏反应
第一节 概述
第二节 围术期过敏反应的机制
第三节 围术期过敏反应诊治的新进展

第十七章 恶性高热
第一节 概述
第二节 恶性高热的诊断与治疗
第三节 恶性高热与基因突变
第四节 恶性高热与酶缺陷
第五节 恶性高热的遗传易感性
第六节 分子生物学技术在恶性高热诊断中应用的新进展

第十八章 脓毒症的发病机制
第一节 脓毒症的定义
第二节 脓毒症与炎症反应
第三节 脓毒症与免疫抑制
第四节 脓毒症的分子遗传学
第五节 脓毒症动物模型

第十九章 脓毒症的生物标志物
第一节 生物标志物的概述
第二节 脓毒症生物标志物的研究进展

第二十章 脓毒症的防治靶标及干细胞治疗
第一节 脓毒症治疗的现状
第二节 脓毒症防治的新靶标及新策略
第三节 脓毒症与干细胞治疗
第四节 展望

第二十一章 ALI／ARDS的发病机制与治疗
第一节 概述与分子机制
第二节 ALl／ARDS的遗传学研究
第二节 AII／ARDS的动物模型
第四节 机械通气相关肺损伤的发生机制

第二十二章 危重病急性及慢性中枢神经系统功能障碍
第一节 危重病中枢神经系统功能障碍概述
第二节 危重病相关中枢神经系统功能的常用研究方法
第三节 危重病急性及慢性中枢神经系统功能障碍的分子机制
第四节 危重病相关的中枢神经系统功能障碍诊断及治疗的分子靶标

第二十三章 细菌耐药性的分子机制及细菌耐药问题的对策
第一节 概述
第二节 细菌耐药的分子机制
第三节 分子生物学技术在细菌耐药研究中的作用
第四节 遏制细菌耐药策略

第二十四章 疼痛相关的基因、神经元和神经传递
第一节 疼痛相关的神经元和神经传递
第二节 疼痛相关的基因和分子机制
第三节 疼痛基因

第二十五章 急性疼痛
第一节 概述
第二节 急性疼痛的传导通路
第三节 急性疼痛的调节机制

第二十六章 慢性疼痛
第一节 慢性疼痛的发生机制
第二节 精神心理因素对慢性疼痛影响的机制
第三节 脊髓损伤后幻肢痛发生的机制
第四节 术后慢性疼痛的发生机制及防治

第二十七章 神经病理性疼痛
第一节 离子通道与神经病理性疼痛
第二节 免疫细胞、神经胶质细胞与神经病理性疼痛
第三节 神经系统各部分在神经病理性疼痛中的作用

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