Trending on TikTok

Buldak

Sunscreen

Sanrio

English

{{sellerTotalView > 1 ? __("sellers", {number: sellerTotalView}) : __("seller", {number: sellerTotalView}) }}, {{numTotalView > 1 ? __("items", {number: numTotalView}) : __("item", {number: numTotalView}) }}

View Cart & Check Out

Nickname

Let us know how to properly address you.

Update Your Name

xxxxxxx@yamibuy.com

Account Orders Favorites

Points 0

Coupons 0

Gift Card Balance $0.00

Sign Out

Change Your Zip Code

Inventory information and delivery speeds may vary for different locations.

Location History

We will notify you by email when the item back in stock.

Your email: {{remindEmail}}

Cancel

Jingdong book

聚乙二醇修饰药物：概念、设计和应用

View Cart & Check Out

{{buttonTypePin == 3 ? __("Scan to view more PinGo") : __("Scan to start")}}

Books Medical Science Pharmacy

Jingdong book

聚乙二醇修饰药物：概念、设计和应用

Name: 聚乙二醇修饰药物：概念、设计和应用
Brand: Jingdong book
SKU: 3117124991
Price: 61.95 USD
Availability: OutOfStock

{{__(":people-members", {'people': item.limit_people_count})}} {{ itemCurrency }}{{ item.valid_price }} {{ itemCurrency }}{{ item.invalid_price }} {{ itemDiscount }}

Ends in

{{ itemCurrency }}{{ priceFormat(item.valid_price / item.bundle_specification) }}/{{ item.unit }}

{{ itemCurrency }}{{ item.valid_price }} {{ itemCurrency }}{{ priceFormat(item.valid_price / item.bundle_specification) }}/{{ item.unit }} {{ itemCurrency }}{{ item.invalid_price }} {{itemDiscount}}

Sale ends in

Sale will starts after Sale ends in

{{ __( "Pay with Gift Card to get sale price: :itemCurrency:price", { 'itemCurrency' : itemCurrency, 'price' : (item.giftcard_price ? priceFormat(item.giftcard_price) : '0.00') } ) }} ({{ itemCurrency }}{{ priceFormat(item.giftcard_price / item.bundle_specification) }}/{{ item.unit }}) Details

Best before

Currently unavailable.

We don't know when or if this item will be back in stock.

Unavailable in your area.

Sold Out

Details

Full product details

Content Description

《聚乙二醇修饰药物：概念、设计和应用》由来自中国科学院、吉林大学、北京林业大学等国家著名研究机构和大学的多位专家共同撰写。作者基于20多年从事聚乙二醇修饰蛋白质研究、教学的经验和国内外相关研究的新进展，对蛋白质的聚乙二醇化学修饰研究领域相关内容进行了较为全面的探讨和阐述，并重点对定点修饰进行了探讨。全书共分为七章，包括：单甲氧基聚乙二醇的合成、单甲氧基聚乙二醇的活化、聚乙二醇修饰蛋白质的反应控制、聚乙二醇.蛋白质偶联物的分离纯化、聚乙二醇.生物大分子偶联物的分析与质量鉴定、聚乙二醇化药物的药代动力学和PEG修饰长效药物。
《聚乙二醇修饰药物：概念、设计和应用》既有对蛋白质的聚乙二醇化学修饰原理的详细阐述，又有对各种修饰剂及修饰方法的设计和过程控制策略的研究，对蛋白质修饰产物的临床应用研究也进行了系统的论述和总结，因此既可作为从事生物化工、药学、医学等学科研究生及研究人员的参考书，亦可为相关行业从业人员提供有益帮助。

Catalogue

前言
写在前面——关于聚乙二醇修饰

第1章单甲氧基聚乙二醇的合成
1．1 聚乙二醇的结构及性质
1．1．1 聚乙二醇链的空间结构
1．1．2 聚乙二醇的物理性质
1．1．3 聚乙二醇的生物学性质
1．1．4 聚乙二醇的化学性质
1．2 聚乙二醇的合成
1．2．1 链引发
1．2．2 链增长
1．2．3 链终止/链转移
1．2．4 单甲氧基聚乙二醇的聚合
1．3 环氧乙烷阴离子聚合制备聚乙二醇的实验技术
1．3．1 单体的储存、纯化与转移操作技术
1．3．2 溶剂的储存、预处理及使用
1．3．3 引发剂的制备及分析
1．3．4 聚合设备
1．4 具有空间结构的聚乙二醇的合成
1．4．1 分枝型聚乙二醇
1．4．2 分叉型聚乙二醇
1．4．3 异端基双官能团聚乙二醇
1．4．4 树状聚乙二醇
1．4．5 多价聚乙二醇
1．5 聚乙二醇及其衍生物的表征
1．5．1 核磁共振
1．5．2 红外光谱
1．5．3 液相色谱/凝胶渗透色谱
1．5．4 基质辅助激光解吸电离飞行时间质谱
1．5．5 显色反应
1．5．6 电泳
1．6 结论与展望
参考文献

第2章单甲氧基聚乙二醇的活化
2．1 聚乙二醇羟基的转化
2．1．1 卤化、磺酸酯化和光延反应
2．1．2 羟基的氧化
2．1．3 以醚键偶联的功能性衍生物
2．1．4 以酯、碳酸酯、氨基甲酸酯偶联的功能性衍生物
2．1．5 其他衍生策略
2．2 用于生物大分子修饰的聚乙二醇衍生物合成
2．2．1 氨基修饰剂的合成
2．2．2 羧基修饰剂的合成
2．2．3 巯基修饰剂的合成
2．2．4 用于精氨酸修饰的聚乙二醇修饰剂
2．2．5 用于二硫键修饰的聚乙二醇修饰剂
2．2．6 可逆聚乙二醇修饰剂
2．2．7 羰基修饰剂的合成
2．3 工业化规模的单甲氧基聚乙二醇衍生物合成
2．3．1 反应系统的设计和搭建
2．3．2 产品的开发
2．4 结论与展望
参考文献

第3章聚乙二醇修饰蛋白质的反应控制
3．1 氨基酸侧链基团的反应控制
3．1．1 赖氨酸
3．1．2 半胱氨酸
3．1．3 天冬氨酸和谷氨酸
3．1．4 精氨酸
3．1．5 组氨酸
3．1．6 糖蛋白的糖基
3．2 聚乙二醇修饰反应的优化
3．2．1 聚乙二醇修饰剂的选择
3．2．2 蛋白质的聚乙二醇修饰条件
3．2．3 聚乙二醇的分子量
3．2．4 通过反应工程控制聚乙二醇修饰
3．3 氨基酸侧链的聚乙二醇定点修饰
3．3．1 酶学催化的聚乙二醇定点修饰
3．3．2 二硫键的聚乙二醇定点修饰
3．3．3 马来酸酐可逆保护蛋白质的氨基
3．3．4．高碘酸钠氧化N一末端具有丝氨酸或苏氨酸的蛋白质
3．3．5 蛋白质的N一末端定点修饰
3．4 化学反应基团的引入与聚乙二醇修饰
3．4．1 基因工程方法引入半胱氨酸
3．4．2 化学合成方法引入半胱氨酸
3．4．3 对天然包埋半胱氨酸的利用
3．4．4 还原抗体的二硫键
3．4．5 化学方法引入巯基
3．4．6 基因工程方法引入非天然氨基酸
3．4．7 基因工程方法引入醛基
3．4．8 基因工程方法缺失赖氨酸
3．5 保护蛋白质活性中心的聚乙二醇修饰方法
3．5．1 保护亲和素亲和位点的修饰方法
3．5．2 保护酶底物结合位点的修饰方法
3．5．3 保护血红蛋白Cys-93 （β）的修饰方法
3．5．4．控制修饰剂比例和分离纯化制备高活性修饰产物
3．6 固相吸附辅助的PEG修饰
3．6．1 离子交换介质辅助的PEG修饰反应
3．6．2 亲和层析介质辅助的PEG修饰反应
3．6．3 分子排阻反应层析
3．6．4 共价层析介质辅助的PEG修饰
3．6．5 微孔疏水相互作用膜辅助的PEG修饰
参考文献

第4章聚乙二醇．蛋白质偶联物的分离纯化
4．1 PEG一蛋白质偶联物的理化特性
4．2 PEG．蛋白质偶联物的分离纯化方法
4．2．1 基于分子量、分子大小的分离纯化方法
4．2．2 基于电荷的分离纯化方法．
4．2．3 基于疏水性的分离
4．2．4 基于亲和作用的分离方法
4．2．5 基于溶解度的分离
4．2．6 最新研究进展
4．3 结论与展望
参考文献

第5章聚乙二醇．生物大分子偶联物的分析与质量鉴定
5．1 分子量和大小（水力学半径）的检测
5．1．1 电泳法
5．1．2 高效液相-尺寸排阻色谱法
5．1．3 质谱法
5．2 浓度的测定
5．2．1 微量凯氏定氮法
5．2．2 双缩脲法
5．2．3 Folin-酚试剂法
5．2．4 考马斯亮蓝法
5．2．5 BCA法
5．2．6 紫外吸收法
5．3 蛋白质二级结构的检测
5．3．1 荧光光谱法
5．3．2 圆二色谱法
5．3．3 核磁共振法
5．4 荷电性质的测定
5．5 免疫性质的测定
5．5．1 蛋白质印迹法
5．5．2 表面等离子体共振法
5．6 位点异构体及修饰位点的检测
5．6．1 PEG-IFN位点异构体及修饰位点的检测
5．6．2 PEG-GCSF修饰位点的检测
5．7 游离PEG残留量的检测
5．7．1 分光光度法
5．7．2 液相色谱一蒸发光散射检测
5．7．3 SDS-PAGE法
5．8 修饰度的检测
5．9 纯度分析
5．9．1 高效液相．尺寸排阻色谱法
5．9．2 反相高效液相色谱法
5．9．3 毛细管电泳结合MALDI-TOFMS法
5．10 结论与展望
参考文献

第6章聚乙二醇化药物的药代动力学
6．1 PEG化药物药代动力学研究分析方法
6．1．1 放射性同位素标记法
6．1．2 生物活性分析法
6．1．3 酶联免疫标记法
6．1．4 电化学发光免疫分析法
6．1．5 比色法
6．1．6 高效液相色谱法
6．1．7 液相色谱一串联质谱法
6．1．8 电泳方法
6．1．9 PEG化药物分析方法的瓶颈与展望
6．2 PEG化药物的药代动力学
6．2．1 直接PEG化药物的药代动力学
6．2．2 PEG化脂质体
6．2．3 PEG化的聚合物胶束
6．2．4 纳米颗粒的PEG化
6．3 结论与展望
参考文献

第7章 PEG修饰长效药物
7．1 PEG修饰药物上市及在研情况
7．1．1 修饰药物的种类
7．1．2 修饰产物结构与性质
7．2 上市PEG修饰长效药物简介
7．2．1 PEG-腺苷脱氨酶（Adagen）
7．2．2 PEG-天冬酰胺酶（（3 ncaspar）
7．2．3 PEG-干扰素α-2 a（Pegasys）
7．2．4 PEG-干扰素α-2 b（Pegintron）
7．2．5 PEG-集落刺激因子（Neulasta）
7．2．6 PEG-生长激素受体拮抗剂（Somavert）
7．2．7 PEG-抗血管内皮生长因子适配体（Macugen）
7．2．8 PEG-促红细胞生成素β（Mircera）
7．2．9 PEG-抗肿瘤坏死因子α抗体Fab'片段（Cimzia）
7．2．10 PEG-重组人尿酸氧化酶（Krystexxa）
7．2．11 PEG-inesatide合成肽（Omontys）
7．3 临床期PEG修饰长效药物简介
7．3．1 PEG-小分子难溶药物
7．3．2 PEG-酶
7．3．3 PEG-细胞因子
7．3．4 PEG-多肽
7．3．5 其他PEG修饰的长效制剂
7．4 PEG修饰药物研究中存在的局限性及解决方向
7．4．1 PEG修饰位点及修饰度的确定
7．4．2 PEG的高分子结构
7．4．3 PEG分子量的大小对药物代谢方式的影响
7．4．4 PEG长效制剂的载药量及释放效率
7．5 结论与展望
参考文献
附录常见PEG修饰剂的合成操作
彩图

Specifications

Brand

Jingdong book

Brand Origin

China

Disclaimer

Product packaging, specifications and price are subject to change without notice. All information about the products on our website is provided for information purposes only. Please always read labels, warnings and directions provided with the product before use.

View Full Terms of Use

Scan to Share

Add to favorites

{{ $isZh ? coupon.coupon_name_sub : coupon.coupon_ename_sub | formatCurrency }}

Clip coupons

Quantity

{{buttonTypePin == 3 ? __("Scan to view more PinGo") : __("Scan to start")}}

Sold by JD@CHINA

Ship to

Free shipping over 69

Genuine guarantee

View details

Region

Added to Cart

Keep Shopping

More to Consider

Coupons

Clip Clipped Over

Expires soon {{ formatTime(coupon.use_end_time) }}

Share this item with friends

Cancel

Yami Gift Card

Get this exclusive deal when paying with gift card

Terms and Conditions

Gift card deals are special offers for selected products;

The gift card deals will automatically be activated if a customer uses gift card balance at check out and the balance is sufficient to pay for the total price of the shopping cart products with gift card deals;

You will not be able to activate the gift card deals if you choose other payment methods besides gift card. The products will be purchased at their normal prices;

If your account balance is not enough to pay for the products with gift card deals, you can choose to reload your gift card balance by clicking on the Reload button at either shopping cart page or check out page;

Products that have gift card deals can be recognized by a special symbol showing 'GC Deal';

For any additional questions or concerns, please contact our customer service;

Yamibuy reserves the right of final interpretation.

Sold by Yami

Service Guarantee

Free Shipping over $49

Easy Returns

Ships from United States

Shipping

United States

Standard Shipping is $5.99 (Excluding Alaska & Hawaii). Free on orders of $49 or more.

Local Express is $5.99 (Available in Parts of CA, NJ, MA & PA). Free on orders of $49 or more.

2-Day Express (Includes Alaska & Hawaii) starts at $19.99.

Return Policy

Yami is committed to provide our customers with a peace of mind when purchasing from us. Most items shipped from Yamibuy.com can be returned within 30 days of receipt of shipment (For Food, Beverages, Snacks, Dry Goods, Health supplements, Fresh Grocery and Perishables Goods, within 7 days of receipt of shipment due to damages or quality issues; To ensure that every customer receives safe and high-quality products, we do not provide refunds or returns for beauty products once they have been opened or used, except in the case of quality issues; Some products may have different policies or requirements associated with them, please see below for products under special categories, or contact Yami Customer Service for further assistance).
Thank you for your understanding and support.

Learn More

Sold by Yami

Terms and Conditions of Yami E-Gift Card

If you choose “Redeem automatically” as your delivery method, your gift card balance will be reload automatically after your order has been processed successfully;

If you choose “Send to Email”as your delivery method, the card number and CVV will be sent to the email address automatically;

Any user can use the card number and CVV to redeem the gift card, please keep your gift card information safely. If you have any trouble receiving email, please contact Yami customer service;

Yami gift card can be used to purchase both Yami owned or Marketplace products;

Yami gift card will never expire;

Yami gift card balance does not have to be used up at once;

Return Policy

Gift card that has already been consumed is non-refundable.

Sold by JD@CHINA

Fulfilled by Yami

Service Guarantee

Free Shipping over $49

Easy Returns

Ships from United States

Shipping

United States

Standard Shipping is $5.99 (Excluding Alaska & Hawaii). Free on orders of $49 or more.

Local Express is $5.99 (Available in Parts of CA, NJ, MA & PA). Free on orders of $49 or more.

2-Day Express (Includes Alaska & Hawaii) starts at $19.99.

Return Policy

You may return product within 30 days upon receiving the product. Items returned must be new in it's original packing, including the original invoice for the purchase. Customer return product at their own expense.

Sold by JD@CHINA

Yami-China FC

Service Guarantee

Cross-store Free Shipping over $69

30-days Return

Yami-China FC

Yami has a consolidation warehouse in China which collects multiple sellers’ packages and combines to one order. Our Yami consolidation warehouse will directly ship the packages to your door. Cross-store free shipping over $69.

Return Policy

You may return products within 30 days upon receiving the products. Sellers take responsibilities for any wrong shipment or missing items. Packing needs to be unopened for any other than quality issues return. We promise to pack carefully, but because goods are taking long journey to destinations, simple damages to packaging may occur. Any damages not causing internal goods quality problems are not allowed to return. If you open the package and any quality problem is found, please contact customer service within three days after receipt of goods.

Shipping Information

Yami Consolidation Service Shipping Fee $9.99(Free shipping over $69)

Sellers in China will ship their orders within 1-2 business days once the order is placed. Packages are sent to our consolidation warehouse in China and combined there. Our Yami consolidation warehouse will directly ship the packages to you via UPS. The average time for UPS to ship from China to the United States is about 10 working days and it can be traced using the tracking number. Due to the pandemic, the delivery time may be delayed by about 5 days. The package needs to be signed by the guest. If the receipt is not signed, the customer shall bear the risk of loss of the package.

Sold by JD@CHINA

Service Guarantee

Free shipping over 69

Genuine guarantee

Shipping

Yami Consolidated Shipping $9.99(Free shipping over $69)

Seller will ship the orders within 1-2 business days. The logistics time limit is expected to be 7-15 working days. In case of customs clearance, the delivery time will be extended by 3-7 days. The final receipt date is subject to the information of the postal company.

Yami Points information

All items are excluding from any promotion or points events on Yamibuy.com

Return Policy

Download the Yami App

Feedback

Back Top

Reviews{{'('+ commentList.posts_count + ')'}}

Have your say. Be the first to help other guests.

Write a review

{{i}} star

{{i}} stars

{{ parseInt(commentRatingList[i]) }}%

{{ showTranslate(comment) }}Show Less

{{ strLimit(comment,800) }}Show more

Show Original

Show All

{{ formatTime(comment.in_dtm) }} VERIFIED PURCHASE {{groupData}}

{{ comment.likes_count }} {{ comment.likes_count }} {{ comment.reply_count }} {{comment.in_user==uid ? __('Delete') : __('Report')}}

{{ showTranslate(comment) }}Show Less

{{ strLimit(comment,800) }}Show more

Show Original

Show All

{{ formatTime(comment.in_dtm) }} VERIFIED PURCHASE {{groupData}}

{{ comment.likes_count }} {{ comment.likes_count }} {{ comment.reply_count }} {{comment.in_user==uid ? __('Delete') : __('Report')}}

No related comment~

Load more reviews

Review

{{ showTranslate(commentDetails) }}Show Less

{{ strLimit(commentDetails,800) }}Show more

Show Original

Show All

{{ formatTime(commentDetails.in_dtm) }} VERIFIED PURCHASE {{groupData}}

Please write at least one word

Comments{{'(' + replyList.length + ')'}}