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常见药用动物的临床应用及药理学研究

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常见药用动物的临床应用及药理学研究

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动物药是一类来源于动物的药物,在世界范围内其在药物研发和疾病的临床治疗等方面有着广泛应用,又因其具有活性强、显效快等特点而备受重视。《常见药用动物的临床应用及药理学研究》共分为5篇,分别详细探讨了虻虫、地鳖虫、蜂毒、蜈蚣和两栖动物5种(类)常见药用动物及其分泌物的临床应用及药理学研究。在每一篇中,首先简要介绍该种(类)动物药在古代典籍中所描述的药效及现代临床对其的应用,之后再详细论述该动物药治疗疾病的作用机制及目前从中所发现的活性组分。
《常见药用动物的临床应用及药理学研究》适用于从事药用动物的应用和药物研发的相关科研工作者,也可供普通读者阅读参考,了解常见药用动物的临床适应证和治疗功效。
Catalogue


前言
第一篇 虻虫的临床应用及药理学研究
第一章 虻虫的一般生物学特征及地鳖虫在古代中医中的应用
第一节 虻虫的一般生物学特征
第二节 虻虫在古代中医中的应用
参考文献
第二章 虻虫在现代临床医学中的应用
第一节 虻虫对心脑血管疾病的治疗作用
第二节 虻虫对其他血管性疾病的治疗作用
一、虻虫对高脂和高纤维蛋白原血症的改善作用
二、虻虫对静脉炎和静脉血栓的治疗作用
第三节 虻虫对肝疾病的治疗作用
第四节 虻虫对肾疾病的治疗作用
第五节 虻虫对糖尿病的治疗作用
一、虻虫对糖尿病肾病的治疗作用
二、虻虫对糖尿病周围神经病变的治疗作用
第六节 虻虫对某些妇科疾病的治疗作用
一、虻虫对子宫内膜异位症的治疗作用
二、虻虫对乳腺增生的治疗作用
三、虻虫对盆腔淤血综合征的治疗作用
第七节 虻虫对某些皮肤病的治疗作用
一、虻虫对银屑病的治疗作用
二、虻虫对痤疮的治疗作用
三、虻虫对某些皮炎的治疗作用
第八节 虻虫对前列腺增生的治疗作用
第九节 虻虫对某些肿瘤的治疗作用
一、虻虫对子宫肌瘤的治疗作用
二、虻虫对肺癌的治疗作用
第十节 虻虫对某些眼科疾病的治疗作用
第十一节 虻虫对其他疾病的治疗作用
参考文献
第三章 虻虫对心脏、大脑及脉管系统的作用研究
第一节 虻虫对心脏的保护作用
一、改善缺血心肌的血供
二、保护冠状动脉血管内皮
三、对缺血性心肌病患者血清脑钠肽的影响
四、抑制心肌细胞凋亡和纤维化
五、抗心律失常
六、治疗病毒性心肌炎
第二节 虻虫对动脉粥样硬化的作用研究
一、动脉粥样硬化发生的病理机制
二、对血小板活化的抑制
三、调节脂质代谢
四、抗凝和纤溶作用
五、对血流动力学改变的影响
六、对血浆凝血酶原时间和活化部分凝血活酶时间的影响
七、对冠状动脉病理改变的影响
八、对内皮细胞功能的影响
第三节 虻虫对脑梗死、脑缺血和脑出血的作用研究
一、引起脑损害的物质基础
二、虻虫治疗脑血管疾病的分子机制
参考文献
第四章 虻虫对肿瘤的作用研究
第一节 虻虫对肝癌的作用研究
第二节 虻虫对肺癌的作用研究
第三节 虻虫对乳腺癌、结肠癌和食管癌的作用研究
第四节 虻虫对荷瘤小鼠的作用研究
参考文献
第五章 虻虫对肺部疾病的作用研究
第一节 虻虫对肺间质纤维化的作用研究
第二节 虻虫对慢性阻塞性肺疾病的作用研究
参考文献
第六章 虻虫对肝纤维化的作用研究
参考文献
第七章 虻虫对肾疾病的作用研究
第一节 虻虫对肾间质纤维化的作用研究
第二节 虻虫对糖尿病肾病的作用研究
参考文献
第八章 虻虫对糖尿病的作用研究
一、糖尿病胰岛素抵抗与其他代谢性疾病
二、Ⅱ型糖尿病的病理机制
三、虻虫对Ⅱ型糖尿病的作用研究
参考文献
第九章 虻虫影响血管生成的作用机制研究
一、血管生成对肿瘤生长的作用机制
二、血管的不正常生成对某些眼科疾病的影响
三、虻虫复方制剂抑制血管生成的作用机制
参考文献
第十章 虻虫对神经元损伤保护和改善认知的研究
一、脑缺血再灌注所致神经损伤的病理机制
二、虻虫对神经损伤的保护作用
参考文献
第十一章 虻虫活性组分的研究
第一节 常见吸血节肢动物唾液腺中的活性物质
一、血液凝固的分子途径
二、吸血昆虫唾液腺分泌物抑制血小板聚集
三、吸血昆虫唾液腺分泌物促使宿主血小板解聚
四、吸血昆虫唾液腺分泌物对凝血级联反应组分(蛋白酶)的抑制作用
五、吸血昆虫唾液腺中的血管舒张因子
六、吸血昆虫唾液腺中的免疫活性物质
七、吸血节肢动物唾液腺其他活性物质
第二节 牛虻唾液腺中的活性物质
一、虻虫唾液腺组分抑制凝血级联反应的发生
二、牛虻唾液腺活性研究及牛虻唾液腺转录组学分析
三、牛虻唾液腺活性物质的分离纯化与鉴定
参考文献

第二篇 地鳖虫的临床应用及药理学研究
第一章 地鳖虫的一般生物学特征及地鳖虫在古代中医中的应用
第一节 地鳖虫的一般生物学特征
第二节 地鳖虫在古代中医中的应用
第二章 地鳖虫在现代临床医学中的应用
第一节 地鳖虫对心脑血管疾病的治疗作用
一、地鳖虫对短暂性脑缺血的治疗作用
二、地鳖虫对静脉血栓的治疗作用
三、地鳖虫对脑出血的治疗作用
四、地鳖虫对脑梗死的治疗作用
五、地鳖虫对心脏病的治疗作用
第二节 地鳖虫对肝疾病的治疗作用
一、地鳖虫对乙型肝炎的治疗作用
二、地鳖虫对肝纤维化及肝硬化的治疗作用
第三节 地鳖虫对骨科疾病的治疗作用
一、地鳖虫对四肢骨损伤的治疗作用
二、地鳖虫对脊柱疾病的治疗作用
三、地鳖虫对关节炎的治疗作用
第四节 地鳖虫对肿瘤的治疗作用
一、地鳖虫对肝癌的治疗作用
二、地鳖虫对非霍奇金淋巴瘤的治疗作用
第五节 地鳖虫对妇科疾病的治疗作用
一、地鳖虫对盆腔炎的治疗作用
二、地鳖虫对子宫内膜异位症的治疗作用
三、地鳖虫对乳腺增生的治疗作用
四、地鳖虫对子宫肌瘤的治疗作用
第六节 地鳖虫对前列腺增生的治疗作用
第七节 地鳖虫对糖尿病及其并发症的治疗作用
参考文献
第三章 地鳖虫对循环系统疾病的作用研究
第一节 地鳖虫对脑出血、脑缺血和脊髓损伤的作用研究
一、地鳖虫对脑出血的作用研究
二、地鳖虫对缺血性脑损伤的作用研究
第二节 地鳖虫对心脏疾病的作用研究
参考文献
第四章 地鳖虫对骨骼系统疾病的作用研究
第一节 地鳖虫对骨折的作用研究
一、促进骨折愈合的相关细胞因子
二、地鳖虫促进骨折愈合的作用机制
第二节 地鳖虫对关节炎的作用研究
参考文献
第五章 地鳖虫对肝纤维化及肝硬化的作用研究
第一节 地鳖虫对肝纤维化的作用研究
第二节 对肝硬化的作用研究
参考文献
第六章 地鳖虫对其他疾病的作用研究
第一节 地鳖虫对肿瘤的作用研究
第二节 地鳖虫对妇科疾病及前列腺增生的作用研究
第三节 地鳖虫对糖尿病及某些免疫性疾病的作用研究
参考文献
第七章 地鳖虫活性组分的研究
第一节 地鳖虫的活性蛋白组分
第二节 地鳖虫体内其他活性成分的研究
参考文献
……
第三篇 蜂毒的临床应用及药理学研究
第四篇 蜈蚣的临床应用及药理学研究
第五篇 两栖动物皮肤活性物质的药理学研究
Book Abstract

《常见药用动物的临床应用及药理学研究》:
蒲晓东观察地鳖虫复方制剂治疗慢性肝炎肝纤维化的临床疗效[45]。研究者选取107例肝纤维化患者并将其随机分为治疗组63例和对照组44例。两组患者年龄、性别、病程等情况无显著差异,具有可比性。其中对照组予以口服虻虫复方制剂,治疗组给予口服地鳖虫复方制剂治疗。根据以下标准来评判疗效:显效为肝纤维化血清学标志物(ⅣC、透明质酸酶、Ⅲ型前胶原及层粘连蛋白含量)有两项以上测定值较治疗前下降50%以上或恢复正常,血清肝功能指标基本恢复正常,症候明显改善;有效为肝纤维化血清学标志物(ⅣC、透明质酸酶、Ⅲ型前胶原及层粘连蛋白含量)有两项测定值较治疗前下降25%以上,血清肝功能指标改善,症候改善,无效为未达到有效标准。经过6个月的治疗,治疗结果显示,治疗组的总有效率为85.48%,而对照组的总有效率为68.18%,两组总有效率比较有显著性差异。在血清肝纤维化指标变化方面,与治疗前相比,治疗组及对照组治疗后ⅣC、透明质酸酶、Ⅲ型前胶原及层粘连蛋白含量均明显降低,其中治疗组降低更为显著。该研究结果表明,虽然虻虫复方制剂也是临床上常用的抗纤维化中药制剂,但其在改善肝纤维化患者肝功能及预防肝纤维化进一步发展方面,其疗效稍逊于地鳖虫复方制剂。
黄晨听等研究地鳖虫复方制剂治疗慢性乙型肝炎肝纤维化的疗效及安全性。研究者将60例患者随机分为治疗组40例和对照组20例。两组患者年龄分布、性别构成、病程、病情等级、肝肾功能、肝纤维四项等经统计学处理,差异均无统计学意义,具有可比性。两组均给予保肝治疗,其中对照组给予虻虫复方制剂,治疗组给予地鳖虫复方制剂口服治疗。经过24周的治疗,治疗组总有效率为87.5%,对照组的总有效率为60.0%,治疗组的总有效率显著高于对照组。与治疗前相比,两组的透明质酸酶、Ⅲ型前胶原及Ⅳ型胶原均降低。在治疗第24周,患者肝功能主要指标谷草转氨酶、谷丙转氨酶、y-谷氨酰转移酶、碱性磷酸酶、总胆红素、白蛋白及凝血酶原时间较治疗前,治疗组改善明显,对照组除总胆红素和碱性磷酸酶外,其余多数指标改善不显著。此外,在治疗过程中,两组均未发现明显不良反应。所以,该研究结果表明地鳖虫复方制剂治疗乙型肝炎肝纤维化安全、有效。
袁建芬的研究进一步肯定了地鳖虫复方制剂对慢性乙型肝炎肝纤维化的良好疗效。研究者将70例慢性乙型肝炎患者随机均分为治疗组和对照组。其中对照组口服虻虫复方制剂,治疗组给予地鳖虫复方制剂治疗。经过6个月的治疗,治疗组总有效率为85.7%,对照组的总有效率为62.9%,两组总有效率比较有显著性差异。在肝功能指标改变方面,两组治疗后谷丙转氨酶和谷草转氨酶均明显降低,与治疗前相比有显著性差异。治疗组总胆红素水平治疗前后比较有显著性差异,与对照组治疗后比较也有显著性差异。但白蛋白水平两组治疗前后比较无明显差异。在改善肝纤维化指标方面,治疗组治疗后各项指标均有下降,且明显优于对照组。
所以,该研究结果说明地鳖虫复方制剂和虻虫复方制剂对肝纤维化患者的临床症状的改善、肝功能及肝纤维化指标的改善均有较好的作用,前者的疗效更为显著。
……

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Yami has a consolidation warehouse in China which collects multiple sellers’ packages and combines to one order. Our Yami consolidation warehouse will directly ship the packages to your door. Cross-store free shipping over $69.

Return Policy

You may return products within 30 days upon receiving the products. Sellers take responsibilities for any wrong shipment or missing items. Packing needs to be unopened for any other than quality issues return. We promise to pack carefully, but because goods are taking long journey to destinations, simple damages to packaging may occur. Any damages not causing internal goods quality problems are not allowed to return. If you open the package and any quality problem is found, please contact customer service within three days after receipt of goods.

Shipping Information

Yami Consolidation Service Shipping Fee $9.99(Free shipping over $69)

Sellers in China will ship their orders within 1-2 business days once the order is placed. Packages are sent to our consolidation warehouse in China and combined there. Our Yami consolidation warehouse will directly ship the packages to you via UPS. The average time for UPS to ship from China to the United States is about 10 working days and it can be traced using the tracking number. Due to the pandemic, the delivery time may be delayed by about 5 days. The package needs to be signed by the guest. If the receipt is not signed, the customer shall bear the risk of loss of the package.

Sold by JD@CHINA

Service Guarantee

Free shipping over 69
Genuine guarantee

Shipping

Yami Consolidated Shipping $9.99(Free shipping over $69)


Seller will ship the orders within 1-2 business days. The logistics time limit is expected to be 7-15 working days. In case of customs clearance, the delivery time will be extended by 3-7 days. The final receipt date is subject to the information of the postal company.

Yami Points information

All items are excluding from any promotion or points events on Yamibuy.com

Return Policy

You may return product within 30 days upon receiving the product. Items returned must be new in it's original packing, including the original invoice for the purchase. Customer return product at their own expense.

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About the brand

Jingdong book

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About the brand

Jingdong book