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Jingdong book

药物发现的未来：谁来决定治疗哪些疾病？

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Books Medical Science Pharmacy

药物发现的未来：谁来决定治疗哪些疾病？

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Content Description

制药产业是所有获准上市药物之源泉，但是，大型医药企业不仅在大规模砍杀研发项目和削减员工，而且不再试图来满足社会对药物的需求。如果政府放任自流，不支持必要的科学研究和不资助必须的临床试验，新型抗生素以及治疗阿尔茨海默病、阻断疼痛和缓解其他疾病的新药将越来越少促使制药工业改变其现行研究和商务方向的激励机制成为亟需。
《药物发现的未来：谁来决定治疗哪些疾病？》这本引人深思之书是最先：解释这对科学家和社会意味着什么；明白如何来确保工业界既急社会所急又保持商业竞争性；为解决制药业、政府和社会所面临的困境提出可节省开支的商务方案。

Comments

★“一个描述医药产业、基于确凿数据和深思熟虑的非凡概要。”
——Michael S Brown（1985年诺贝尔生理学或医学奖获得者，美国德州大学西南医学中心）

★“这是一本非凡、睿智和引人深思的书，值得所有对生物医药发展感兴趣的人（从科学家到政治家）一读。”
——Jean—Pierre Changeux（法兰西学院和巴斯德研究所）

★“Bartfai和Lees提出了新药发现所面临的关键问题。他们的分析很有说服力，他们的想法深刻而发人深省。对任何好奇新药将来自何方以及生物医药产业将作出哪些努力才能为阿尔茨海默病、糖尿病、抑郁症和癌症等疾病带来新的治疗方法的人来说，这是一本必读的书。”
——MichaeI D Ehlers（辉瑞资深副总裁和神经科学首席科学家，美国杜克大学前霍华德休斯研究员）

★“这是一本学生、开处方的医师、学界和工业界科研人员、分析师、患者群体、商务与科学记者、尤其是决策者所必读的书。药物开发是一种比以往任何时候都更为复杂的科学化、工业化和社会化的努力，需要政府、科研院所和大型制药公司共同为之，不仅仅是华尔街。”
——Daniel Hoyer（澳大利亚墨尔本大学药理系主任，诺华公司前主要科学家）

Catalogue

中文版序
译者简介
译者的话
序
Graeme Bible博士的序
James H Eberwine博士的序
Eduard Enrico Holdener博士的序
原著作者简介

第O章介绍
你可能需要什么药物而你又为何无法获得它们
衰老是疾病的主要危险因素
痛苦的现实和阿尔茨海默病
需要政府更多的参与
进入市场的果断和迟疑
政府能够改变未来
情况并不都是那么不幸与黯淡
社会能做什么

第1章尽管大药企的药物开发正处“危机”，为何仍有新药
陷于危机和合并中的制药产业
表1.1 最常见的疾病：美国的发病情况
表1.2 按照收入、雇员人均盈利和市值排名的前12位制药公司
为什么坚信未来的新药将会产生
表1.3 将来为何会有很多新药
新指征的安全药物：新疗法并非总需要新药
预防性药物：大规模、漫长、昂贵和确证的试验
年龄作为危险因子和警惕成本花费
新近孤儿化的疾病：更需要政府之参与

第2章对药物需求的增长
小分子药物和生物技术药
表2.1 驱动医药销售增长的因素
老龄化的人口
罕见病或“孤儿病”
表2.2 最贵的治疗“孤儿病”生物技术药
药物开发：增加生物技术药
MS的治疗
图2.1 治疗MS的小分子药物和生物技术药
表2.3 目前临床上使用的MS药物
RA的治疗
图2.2 RA：1998年至2011年的治疗历史与开支
重组蛋白用于治疗
未来用于治疗的重组蛋白
表2.4 为治疗和接种目的而制造的几大组重组蛋白和疫苗
表2.5 私营产业对未来药物开发的要求
药企、政府和非政府组织
表2.6 顶级药企研究的“核心”治疗领域

第3章药物正变得更好：过去几十年里的突破性药物
二战以来的显著进展
极其赚钱的药物发现之辉煌开端和可怕结局
药物发现回击第一阶段
药物发现真的被套牢
荟萃分析是有用的：旧信息的新诠释
安全药物的新用途
表3.1 新药研发必须和必将继续的原因
……
第4章我们想要治疗哪些疾病？
第5章治疗领域：未来战略性重要的疾病
第6章重磅炸弹式药物与仿制药相比
第7章制药业为什么是特殊产业？
第8章朝向个性化医疗的诊断
第9章个性化医疗
第10章药物价钱可以是多少？
第11章为2025年前的药物发现构建模式
第12章 2010-2025年间的药物开发模式
索引

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