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Jingdong book

北京协和医院处方手册(第4版)

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北京协和医院处方手册(第4版)

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《北京协和医院处方手册(第4版)》系根据药剂科和各临床科室在工作的实践经验及用药习惯特点,总结编纂而成。
Catalogue

一、抗感染药
二、主要作用于蹼枢神经系统的药物
三、作用于自主神系统的药物
四、主要作用于心血管系统的药物
五、主要作用于呼吸系统的药物
六、主要作用于消化系统的药物
七、影响血液及造血系统的药物
八、主要作用于泌尿和生殖系统的药物
九、激素及其有关药物
十、主要影响变态反应和免疫功能的药物
十一、抗肿瘤药物
十二、维生素类、酶制剂以及调节水、电解质和酸碱平衡的药物、营养类药物
十三、各科用药
附录
中文索引
英文索引
Book Abstract

[临床应用] 用于耐甲氧西林金黄色葡萄球菌和耐氨苄西林肠球菌所致的感染(对中枢感染无效)。皮肤和软组织感染、泌尿道感染、呼吸道感染、骨和关节感染、败血症、心内膜炎及腹膜炎。成人:首剂量(第一日)400mg,自第二日开始每日200mg,肌内注射、静脉注射(注射时间为3—5分钟)和静脉滴注(滴注时间不少于30分钟);严重感染:每次400mg次/日,3日后减为200—400mg/d,疗程长短根据感染的类型、严重程度和病人的临床反应而定。心内膜炎和骨髓炎的疗程则推荐为3周或更长时间。
2个月以上儿童:严重感染和中性粒细胞减少,推荐剂量10mg/kg,前三剂负荷剂量每12小时静脉注射一次,随后剂量10mg/kg,静脉或肌内注射,每日一次。对中度感染,推荐剂量10mg/kg,前三剂负荷剂量每12小时静脉注射1次,随后维持剂量为6mg/kg,静脉或肌内注射,1次/日。小于2个月的婴儿:第一日的推荐负荷剂量为16mg/kg,只用1次,随后8mg/kg,1次/日。静脉滴注时间不少于30分钟。
[注意事项] 本品与万古霉素可能有交叉过敏反应,对万古霉素过敏者慎用。妊娠期妇女慎用。不良反应有血清转氨酶、血清碱性磷酸酶增高;血清肌酐短暂升高。用药期间同时或相继使用有听神经毒性和肾毒性的其他药物(如氨基糖苷类、多黏菌素、两性霉素B、呋塞米、环孢菌素和顺铂)时需监测肾功能和听力。
[规格] 注射剂:200mg/支
替加环素(Tigecycline)
[异名] 泰阁(Tygacil)
本品的作用机制是通过与核糖体30S亚单位结合,阻止氨酰化tRNA分子进入核糖体A位而抑制细菌蛋白质合成,限制细菌的生长。
[临床应用] 用于18岁以上患者在下列情况下由特定细菌的敏感菌株所致感染的治疗:复杂性腹腔内感染——弗劳地枸橼酸杆菌、阴沟肠杆菌、大肠埃希菌、产酸克雷伯菌、肺炎克雷伯菌、粪肠球菌(仅万古霉素敏感株)、金黄色葡萄球菌(仅甲氧西林敏感株)、咽峡链球菌属(包括咽峡炎链球菌、中间链球菌和星座链球菌)、脆弱拟杆菌、多形拟杆菌、单形拟杆菌、普通类杆菌、产气荚膜梭菌、微小消化链球菌等所致者。静脉滴注:首剂量100mg,维持剂量为50mg,每12小时静脉滴注1次;每次滴注时间为30一60分钟。治疗复杂腹内感染的推荐疗程均为5—14天,疗程应根据感染的严重程度及部位和患者临床、细菌学进展情况而定。
……

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