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Jingdong book

心脏电生理：从细胞到临床（第4版）

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Jingdong book

心脏电生理：从细胞到临床（第4版）

Name: 心脏电生理：从细胞到临床（第4版）
Brand: Jingdong book
SKU: 3117043901
Price: 155.30 USD
Availability: OutOfStock

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Content Description

对于基础研究的科学家、基础和临床心脏电生理学家以及心内科医生来说，全新改版的《心脏电生理学：从细胞到临床》第四版仍是学习和洞悉心脏电生理学及最新进展的可靠宝库。来自不同专业领域的精英撰写了本书各章精湛丰富的内容。本书就像副标题“从细胞到临床”暗示的两方面内容。本版坚守往版确定的作为本领域完备参考书的传统。前51章为心脏电生理学基础研究的内容，后69章是心律失常临床方面的内容。通过本书读者可以了解世界顶尖专家的最新研究进展。
基础研究新的章包括：如HCN的分子和结构基础，张力激活和内流放大通道。收缩一兴奋反馈新章介绍了心脏机械活动调节电学功能的方式。神经再生和心律失常章介绍了心肌梗死后交感神经再生所导致的神经重构进而引起心肌组织的电重构，并形成室速或室颤的触发因子。关于心房颤动的两章介绍了肺静脉中局灶电活动引发的房颤发作，以及左房后部及肺静脉区域的局灶折返引起的急性房颤的持续和向右房的扩布。有关室颤一章讨论了强的内流放大钾通道与室颤可能有关的转子稳定中的作用。有关心律失常的基因敲除和转基因动物模型的新章，回顾了建立鼠模型和研究电学功能的方法并分析了目前与心脏电生理学有关的遗传模型。另一方面，在药物遗传学与心律失常的章中讨论了基因组中多个DNA变异对药物反应的调节模式。临床相关新章包括Brugada综合征、儿茶酚胺和短联律间期室速以及植人式Holter的临床应用等。此外，介绍了新的标测技术并详细介绍了最新非传统的抗心律失常药物，以及房颤导管消融的最新研究成果和房颤发生中肺静脉的作用。
总之，读者将了解心脏电活动的分子和细胞基础，心律失常的机制，如何检测猝死的高危患者，如何评价患者病情，如何使用电学、手术或药物治疗。显然，本书的独特性在书的副标题中已经得到体现，读者在本书可获得心脏电生理学基础和临床方面的各种知识。这是《心脏电生理学：从细胞到临床》一书
最重要的特点。
临床心脏电生理学仍在持续不断地快速发展，因此，不久的将来，读者将会发现本版书中许多概念是错误的。但我们相信本书对心脏电生理学感兴趣的人来说未来数年间仍是有用的参考书。

Author Description

郭继鸿，男，1949年生，现任北京大学人民医院教授、主任医师、博士生导师、心内科副主任、心脏电生理室主任，中国心电学会主任委员、中国心律学会主任委员、中国心电学网首席顾问、中华医学会心电生理和起搏学分会常委、秘书长，中国心功能学会常委，中华心律失常学杂志副主编，中华医学杂志编委，中国实用内科杂志常委，《临床心电学杂志》主编，心血管诊疗技术杂志主编等职务。
李学斌，男，1964年9月生，1988年承德医学院获学士学位，1997年获北京医科大学医学硕士学位。自1994年至今一直在北京大学人民医院主要从事心律失常的临床和基础研究，尤其在射频消融和心脏起搏方面作了大量的临床工作，截止目前共完成各种类型室上性心动过速、不良性窦速、心房扑动、房性心动过速、室性心动过速、阵发性心房颤动等射频消融根治术数千例，其中仅儿童病例多达数百例，植入永久心脏起搏器及ICD达上千例，并指导全国上百家医院开展了心脏病介入治疗，完成了许多疑难病例的射频消融和起搏器植入。

Catalogue

第一部分离子通道功能的结构与分子基础
第1章钠通道
第2章钙通道
第3章电压调节性钾通道
第4章细胞内信号系统与心脏离子通道的调节
第5章膜泵和离子交换
第6章肌浆网离子通道
第7章 HCN通道：从基因到功能
第8章心脏缝隙连接蛋白43的分子组成和调节

第二部分心脏离子通道的生物物理学
第9章正常和异常钠通道的生物物理学
第10章心脏门控延迟整流钾通道
第11章机械电转换
第12章起搏通道和正常的自律性
第13章内向整流钾通道的生物物理学特性
第14章同源和异源缝隙连接通道

第三部分心脏离子通道的分子问作用和药理学
第15章心脏钠通道药理学
第16章心脏L型和T型钙电流的药理学
第17章 KCNOI／KCNEI分子信号复合物：通道微结构与人体疾病
第18章药物诱发的通道病
第19章缝隙连接通道药理学靶点的前景

第四部分离子通道与细胞电生理学
第20章哺乳动物心肌钾通道的异源性表达
第21章心脏缝隙连接的分布和调节
第22章窦房结活动的细胞机制
第23章房室结的兴奋性及其传导机制
第24章细胞问的交流和电冲动的传导
第25章心脏组织结构决定冲动传导的速度和安全性
第26章致心律失常的基础：恢复、复极和交替
第27章机械电转换／反馈：普遍性及病理生理学意义

第五部分心脏兴奋的模型
第28章心脏电活动的离子机制：理论探索
第29章心肌中电激动的二维传导
第30章数学模型中电激动的三维传导
第31章心脏除颤模型

第六部分心脏电活动的中枢调节
第32章 β和α肾上腺素受体调节心脏节律的分子和细胞基础
第33章神经的新生与心律失常
第34章胆碱能性心房颤动
第七部分非线性动力学、螺旋波和心脏节律
第八部分心律失常发生的机制
第九部分分子遗传学和药物基因组学
第十部分临床心律失常：机制、表现和处理
第十二部分诊断与评价
第十三部分临床综合征：认识、临床过程和处理
第十四部分心律失常的药物和非药物治疗

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