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Jingdong book

临床路径管理丛书·肾病科临床路径

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临床路径管理丛书·肾病科临床路径

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临床路径是应用循证医学证据,综合多学科、多专业主要临床干预措施所形成的“疾病医疗护理计划标准”,是医院管理进一步精细化,逐步深入到单病种管理的体现。《临床路径管理丛书:肾病科临床路径》既包含了循证医学理念,具有科学性、规范性、可操作性的特点,又融入了“以病人为中心”等现代医疗质量管理理念和模式,贴近临床、贴近患者,对于保障医疗质量与安全、规范诊疗行为、控制医疗费用具有重要的现实意义。
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终末期肾脏病临床路径
狼疮性肾炎行肾穿刺活检临床路径
急性肾损伤临床路径
IgA肾病行肾穿刺活检临床路径
I型新月体肾炎血浆置换治疗临床路径
腹膜透析并发腹膜炎临床路径
急性肾盂肾炎临床路径
急性药物过敏性间质性肾炎临床路径
终末期肾脏病常规血液透析治疗临床路径
慢性肾脏病贫血临床路径
附件1 卫生部关于开展临床路径管理试点工作的通知
附件2 卫生部办公厅关于进一步加强临床路径管理试点工作的通知
Book Abstract

(4)24小时尿蛋白定量、尿沉渣检查; (5)B超(双肾、肝胆脾胰)、X线胸片、心电图、超声心动图。2.根据患者病情,必要时检查:(1)外周血CD4+和CD8+细胞、ANCA、抗GBM抗体、血清蛋白电泳、甲状腺功能; (2)双肾血管彩超、头颅MRI、骨髓穿刺、骨盆X线片、肌电图、脑电图、眼底检查等。3.对系统性红斑狼疮疾病活动性指数(SLE—DAI)进行评分。4.如患者无禁忌,应行肾活检病理检查,明确病理类型,以指导治疗,估计预后。(六)肾穿刺前用药 1.控制系统性红斑狼疮活动,可使用糖皮质激素等免疫抑制剂。2.根据病情,积极纠正水、电解质、酸碱平衡紊乱(可使用利尿剂、碱剂或扩容治疗)。3.控制血压,保护肾功能。4.加强对症支持治疗:必要时酌情使用促红细胞生成素、粒细胞集落刺激因子或他汀类降脂药。5.肾穿刺术前停用抗凝药物。6.必要时抗感染治疗。(七)肾穿刺病理检查 如果患者入院前已完成穿刺前的检查和准备,住院后即可进行肾活检。如果患者住院后开始安排肾活检前的检查和准备,则在完成评估后行肾活检。1.麻醉方式:局部麻醉。2.术前准备:停用一切抗凝药物后,复查凝血功能正常;血红蛋白8g/d1以上,血小板80×109/L;血压控制在140/90mmHg以下。3.术中用药:麻醉常规用药。4.取材方式:经皮肾活检。5.输血:视术中情况而定。6.组织病理:冰冻切片行免疫荧光检查、石蜡切片光镜检查及电镜检查,并对肾组织活动陛指数(AI)、慢性指数(DI)进行评分。(八)穿刺后用药 1.肾穿刺术后根据情况选择性使用止血药。2.根据临床情况可选择性使用无肾毒性抗菌药物,按《抗菌药物临床应用指导原则》(卫医发[20043285号)执行。3.根据肾活检病理诊断,确定病理类型后实施治疗方案:(1)重型狼疮性肾炎,疾病明显活动者,可考虑大剂量激素静脉冲击治疗,环磷酰胺冲击治疗或麦考酚吗乙酯、普乐可复治疗;如伴免疫功能缺陷可以考虑大剂量丙种球蛋白冲击治疗或血浆置换; (2)病情相对稳定,无明显狼疮活动者,可考虑激素联合雷公藤总苷、硫唑嘌呤或来氟米特等治疗; (3)在肾穿刺7天后,无活动性出血,可酌情予抗凝药、抗血小板药治疗(促纤维蛋白溶解药慎用); (4)保护肾功能、对症支持治疗。(九)出院标准 1.没有需要住院处理的并发症和(或)合并症。2.肾穿刺伤口愈合好。3.临床症状(血压、蛋白尿、血尿和肾功能)稳定或者好转。(十)变异及原因分析 1.出现肾功能急剧恶化、恶性高血压等严重并发症,需要在住院期间处理。2.新出现其他系统合并症,如血液系统、神经系统症状需要住院治疗。3.出现治疗相关的并发症如感染、血糖升高或肾穿刺并发症,需要住院期间处理。

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